1. AlphaGenome: AI for better understanding the genome
343 points by i_love_limes | 103 comments

2. How much slower is random access, really?
31 points by sestep | 5 comments

3. The time is right for a DOM templating API
65 points by mdhb | 40 comments

4. Save your disk, write files directly into RAM with /dev/shm
40 points by hiAndrewQuinn | 34 comments

5. Show HN: Magnitude – Open-source AI browser automation framework
42 points by anerli | 15 comments

6. Alternative Layout System
93 points by smartmic | 13 comments

7. Matrix v1.15
102 points by todsacerdoti | 30 comments

8. Kea 3.0, our first LTS version
40 points by conductor | 18 comments

9. Robots that learn
76 points by ulrischa | 20 comments

10. Snow - Classic Macintosh emulator
191 points by ColinWright | 68 comments

11. A Review of Aerospike Nozzles: Current Trends in Aerospace Applications
62 points by PaulHoule | 30 comments

12. Senators reintroduce App Store bill to rein in 'gatekeeper power'
60 points by janandonly | 33 comments

13. Introducing Gemma 3n
265 points by bundie | 119 comments

14. Fault Tolerant Llama training – PyTorch blog
6 points by Mougatine | 1 comments

15. A new pyramid-like shape always lands the same side up
614 points by robinhouston | 150 comments

16. Puerto Rico's Solar Microgrids Beat Blackout
341 points by ohjeez | 193 comments

17. Shifts in diatom and dinoflagellate biomass in the North Atlantic over 6 decades
39 points by PaulHoule | 2 comments

18. Show HN: I built an AI dataset generator
115 points by matthewhefferon | 22 comments

19. “Why is the Rust compiler so slow?”
137 points by Bogdanp | 144 comments

20. Memory safety is table stakes
62 points by comradelion | 56 comments

21. Typr – TUI typing test with a word selection algorithm inspired by keybr
32 points by Sakura-sx | 21 comments

22. Starcloud can’t put a data centre in space at $8.2M in one Starship
39 points by angadh | 45 comments

23. Lateralized sleeping positions in domestic cats
90 points by EvgeniyZh | 46 comments

24. Access BMC UART on Supermicro X11SSH
54 points by pietrushnic | 10 comments

25. Ambient Garden
295 points by fipar | 51 comments

26. The Business of Betting on Catastrophe
61 points by anarbadalov | 29 comments

27. “My Malformed Bones” – Harry Crews’s Counterlives
5 points by Caiero | 0 comments

28. Muvera: Making multi-vector retrieval as fast as single-vector search
87 points by georgehill | 7 comments

29. Writing a basic Linux device driver when you know nothing about Linux drivers
414 points by sbt567 | 58 comments

30. US economy shrank 0.5% in the first quarter, worse than earlier estimates
282 points by Aloisius | 100 comments

31. Better Auth, by a self-taught Ethiopian dev, raises $5M from Peak XV, YC
250 points by bundie | 167 comments

32. FLUX.1 Kontext [Dev] – Open Weights for Image Editing
121 points by minimaxir | 35 comments

33. Build and Host AI-Powered Apps with Claude – No Deployment Needed
314 points by davidbarker | 136 comments

34. Structured Output with LangChain and Llamafile
41 points by brakmic | 18 comments

35. Modeling the World in 280 Characters
98 points by OuterVale | 14 comments